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Samaneh Bandehali, Sciprofile linkAbdolreza Moghadassi, Fahime Parvizian, Yatao Zhang, Sayed Mohsen Hosseini, Sciprofile linkJiangnan Shen
Published: 22 February 2020
Separation and Purification Technology; doi:10.1016/j.seppur.2020.116745

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Deepa M. Sridharan, Lung-Chang Chien, Francis A. Cucinotta, Sciprofile linkJanice M. Pluth
Published: 22 February 2020
Life Sciences in Space Research; doi:10.1016/j.lssr.2020.02.002

Abstract: During space travel astronauts will be exposed to a very low, mixed field of radiation containing different high LET particles of varying energies, over an extended period. Thus, defining how human cells respond to these complex low dose exposures is important in ascertaining risk. In the current study, we have chosen to investigate how low doses of three different ion's at various energies uniquely change the kinetics of three different phospho-proteins. A normal hTERT immortalized fibroblast cell line, 82-6, was exposed to a range of lower doses (0.05-0.5 Gy) of radiation of different qualities and energies (Si 1000, Si 300, Si 173, Si 93, Fe 1000, Fe 600, Fe 300, Ti 300, Ti326, Ti386 MeV/u), covering a wide span of LET's. Exposed samples were analyzed for the average intensity of signal as a fold over the geometric mean level of the sham controls. Three phospho-proteins known to localize to DNA DSBs following radiation (γH2AX, pATF2, pSMC1) were studied. The kinetics of their response was quantified by flow cytometery at 2 and 24 h post exposure. These studies reveal unique kinetic patterns based on the ion, energy, fluence and time following exposure. In addition, γH2AX phosphorylation patterns are uniquely different from phospho-proteins known to be primarily phosphorylated by ATM. This latter finding suggests that the activating kinase(s), or the phosphatases deactivating these proteins, exhibit differences in their response to various radiation qualities and/ or doses of exposure. Further studies will be needed to better define what the differing kinetics for the kinases activated by the unique radiation qualities plays in the biological effectiveness of the particle.
A. Le Helley, H. Pla, C. Eloi, M. Balençon, C. Sicotte
Published: 22 February 2020
Children and Youth Services Review; doi:10.1016/j.childyouth.2020.104883

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International Journal of Mechanical Sciences; doi:10.1016/j.ijmecsci.2019.105396

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Published: 22 February 2020
Preventive Veterinary Medicine; doi:10.1016/j.prevetmed.2020.104938

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V.A. Ignatchenko, D.S. Tsikalov
Journal of Magnetism and Magnetic Materials; doi:10.1016/j.jmmm.2020.166643

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Sciprofile linkDavid Carvallo, Rodrigo Retamal
Forensic Science International: Reports; doi:10.1016/j.fsir.2020.100077

Abstract: Sex estimation is fundamental for the identification of skeletonized human remains in forensic contexts. The methods most often used are based on pelvis and skull morphology evaluation. When these elements are not available due to poor preservation, other bone elements, such as the femur, can be used given its good preservation and marked sexual dimorphism. Particularly, the proximal end of the femur is the most dimorphic region of this bone, so its evaluation is especially useful for sex estimation. A set of new sex estimation models were elaborated utilizing 8 metric variables from the proximal end of the femur in a modern Chilean sample of 270 individuals (200 individuals for training, 70 individuals for validation) from the Santiago Modern Osteological Collection. Sex estimation models were calculated using logistic regression. Results showed that the models based on the femoral neck measurements are the best sex estimators, with up to 92.9% (univariable models) and 95.7% (multivariable models) of overall accuracy and low sex bias. The models proposed here are the most accurate reported to date for modern Chilean population. They and can contribute toward the identification of human remains in cases of Human Rig’hts violations committed during the Civil-Military Dictatorship in Chile (1973-1990).
Sciprofile linkPaula Vicente, Ana Sampaio, Elizabeth Reis
Published: 22 February 2020
Case Studies on Transport Policy; doi:10.1016/j.cstp.2020.02.004

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Published: 22 February 2020
Expert Systems with Applications; doi:10.1016/j.eswa.2020.113334

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