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Luís Costa-Marques, Katrin Arnold, Marie-Christine Pardon, Christiane Leovsky, Samantha Swarbrick, Claire Fabian, Alexandra Stolzing
Translational Neurodegeneration, Volume 8, pp 1-11; doi:10.1186/s40035-019-0173-9

Abstract: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. BM-M were transplanted into the tail vein and the animals analysed 1 month later. BM-M transplantation promoted the reduction of the amyloid beta [37-42] plaque number and size in the cortex and hippocampus of the treated mice, but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques. The number of phenotypically ‘small’ microglia increased in the hippocampus. Astrocyte size decreased overall, indicating a reduction of activated astrocytes. Gene expression of interleukin 6 and 10, interferon-gamma, and prostaglandin E receptor 2 was significantly lower in the hippocampus, while interleukin 10 expression was elevated in the cortex of the treated mice. BM-M systemically transplanted, promote a decrease in neuroinflammation and a limited reversion of amyloid pathology. This exploratory study may support the potential of BM-M or microglia-like cell therapy and further illuminates the mechanisms of action associated with such transplants.
Artur Azarov, Olga Vasileva, Tatiana Tulupyeva
Communications in Computer and Information Science pp 218-225; doi:10.1007/978-3-030-30763-9_18

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Dmitry Devyatkin
Communications in Computer and Information Science pp 189-200; doi:10.1007/978-3-030-30763-9_16

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Brigitte Laforest, Wenli Dai, Leonid Tyan, Sonja Lazarevic, Kaitlyn M. Shen, Margaret Gadek, Michael T. Broman, Christopher R. Weber, Ivan P. Moskowitz
Journal of Clinical Investigation; doi:10.1172/jci124231

Alena Gros, Eric Tran, Maria R. Parkhurst, Sadia Ilyas, Anna Pasetto, Eric M. Groh, Paul F. Robbins, Rami Yossef, Andrea Garcia-Garijo, Carlos A. Fajardo, et al.
Journal of Clinical Investigation; doi:10.1172/jci127967

Jennifer L. Larson-Casey, Mudit Vaid, Linlin Gu, Chao He, Guo-Qiang Cai, Qiang Ding, Dana Davis, Taylor F. Berryhill, Landon S. Wilson, Stephen Barnes, et al.
Journal of Clinical Investigation; doi:10.1172/jci127959

Christodoulos Kaoutzanis, Steven J Schneeberger, Blair Wormer, Haocan Song, Fei Ye, Salam Al Kassis, Julian Winocour, Kent Higdon, Galen Perdikis
Aesthetic Surgery Journal; doi:10.1093/asj/sjz276

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Dino Elyassnia
Aesthetic Surgery Journal; doi:10.1093/asj/sjz270

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