Hidradenitis Suppurativa, Eruptive Melanocytic Nevi, and Keratosis Pilaris–like Eruption in a Patient Treated With Vemurafenib

Abstract

We report a case of hidradenitis suppurativa and eruptive melanocytic nevi associated with a keratosis pilaris (KP)-like eruption from vemurafenib, lending further insight into keratinocyte differentiation and melanocyte proliferation pathways. A 51-year-old man with a history of an 8-mm nodular melanoma on the scalp underwent wide local excision with radical lymph node dissection. Nineteen of 23 lymph nodes were found to be positive for disease, and he underwent 1 year of high-dose interferon alfa-2b therapy in 2009. After recurrent lymphatic disease was found on positron-emission tomography in March 2010, he underwent another right posterior neck lymph node dissection followed by irradiation. Over the next year, multiple chemotherapy regimens including temozolomide and carboplatin/paclitaxel failed to halt disease progression.