A Review: Artemisinin-Based Combination Therapies [ACTs] and K13 Polymorphism
Open Access
- 13 August 2020
- journal article
- review article
- Published by SciRes Literature LLC in Journal of Biomedical Research & Environmental Sciences
- Vol. 1 (4), 088-091
- https://doi.org/10.37871/jels1124
Abstract
Malaria is caused by four plasmodium species in humans (P. falciparum, P. vivax, P. malariae and P. ovale) which spread from one person to another via the bite of female Anopheles mosquito. P. falciparum causes most deaths from malaria [1] and is most prevalent on the African continent whereas P. vivax has a wider geographical distribution [2]. According to the latest WHO estimates, released in December 2015, there were 214 million cases of malaria in 2015 and 438,000 deaths [3]. Existing strategies to control malaria include vector control, chemoprevention and case management [4]. Without a fruitful antibody that would offer security against malaria, we have to depend on anti-malarial prescription to treat just as lessen the odds of getting the disease [5-8]. Artemisinin in mix with other moderate acting medications is suggested for the treatment of P. falciparum [9,10].Keywords
This publication has 25 references indexed in Scilit:
- Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasionNature Communications, 2015
- Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitorsEuropean Journal of Medicinal Chemistry, 2015
- Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular markerThe Lancet Infectious Diseases, 2015
- The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human ErythrocytesPLoS Pathogens, 2014
- Targeting Plasmodium PI(4)K to eliminate malariaNature, 2013
- A thrombospondin structural repeat containing rhoptry protein fromPlasmodium falciparummediates erythrocyte invasionCellular Microbiology, 2013
- Identification of a Potent Combination of Key Plasmodium falciparum Merozoite Antigens That Elicit Strain-Transcending Parasite-Neutralizing AntibodiesInfection and Immunity, 2013
- Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast AsiaProceedings of the National Academy of Sciences of the United States of America, 2012
- The cellular and molecular basis for malaria parasite invasion of the human red blood cellThe Journal of cell biology, 2012
- Understanding the population genetics of Plasmodium vivax is essential for malaria control and eliminationMalaria Journal, 2012