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Reassessment of serum level of testosterone in female with acne vulgaris

Naseem Mohammed Farhan, Mustafa Suhail Najem, Khalid Ibrahim Jasim, Nael Murad Dawood, Wisam Suhail Najem

Abstract: Background: Acne is a chronic inflammatory skin disease of pilosebaceous follicle. Acne primarily is seen in adolescent. The clinical lesions are non-inflammatory comedonal open (blackhead) and closed (whitehead) and/ or inflammatory papules, pustules and nodules. After puberty, in male and female, hormone called androgens appears to be a part of the underlying mechanism, by increased sebum production. Aim of study: To identify the correlation between testosterone hormone and acne vulgaris in female compare it withhealthy control. Material and Methods: A case-control study was carried out from November 2019 to May 2020 in the consultation Department of Dermatology and Venerology at Salahaddin General Hospital. The researcher selected 60 female patients included 30 patients with acne vulgaris as a case and compared with 30 female without acne vulgaris then, testosterone test of cases was compared with that of equal number of age and sex matched healthy controls. Results: The sixty female patients who were included in this study, are of age range (14-35years) mean± stander deviation (21.59±4.28) for case group and (21.34± 3.31) for control group. The result of the study showed that the mean of free testosterone among cases was (3.44 ±0.64) three time more than control group (1.79±0.41) with significant difference (p= 0.001), and serum total testosterone the result found that the mean is also more in case group than the control group (0.77, 0.22, SD = 0.16, and 0.22 respectively) with statically significant association (p=0.001). Conclusions: Significant difference in hormonal level of Testosterone (free and total) and estradiol between acne group and control group.
Keywords: testosterone / hormone / female / acne vulgaris / serum / level / control group

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