Regulation of NF-Kappa B Signaling Pathway by Hepatitis Viruses

Abstract

先天免疫应答是机体抵抗病毒感染的第一道防线。NF-κB信号通路作为先天免疫应答的重要部分，能够通过促进多种细胞因子产生而抵抗病原体的入侵。病毒可通过抑制NF-κB表达，逃逸宿主免疫反应，而有些病毒则可利用NF-κB的活化，促进自身的复制。肝炎病毒是引起病毒性肝炎的一大类病原体。目前，有关肝炎病毒对NF-κB信号通路的调控还没有系统的文献报道，本文将就乙型、丙型、丁型、戊型四种肝炎病毒对NF-κB信号通路的调控进行综述。 The innate immune response is the first line of host against viral infection. As an important part of the innate immune response, NF-kappa B (NF-κB) signaling pathway can protect host against patho-gen invasion by activating the production of cytokines. Viruses can inhibit the expression of NF-κB by escaping the host immune response, while some viruses can use the activation of NF-κB to promote replication. Hepatitis viruses are the major pathogens of viral hepatitis. Up to now, there is no comprehensive report about the relationship between hepatitis viruses and NF-κB signaling pathway. The regulation of NF-κB signaling pathway during hepatitis viruses (B, C, D and E) infection was summered to clarify the interaction between NF-κB signaling pathway and hepatitis viruses.