Alkaloids are nitrogen-containing organic compounds that are widely used in medicine for the treatment of cardiovascular, gastrointestinal, nervous, tumor pathologies. The aim of the research was to study the species diversity of alkaloid-containing plants, distribution areas, habitats and peculiarities of use in the floristic region of Adjara. According to the research, 35 species of alkaloids are distributed in the floristic region of Adjara, which are united in 24 families and 32 genera, including 28 species of the genus Orlebnia, 7 species of the genus Erlebnia, 1 species is representative of the fungal kingdom.