IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation
- 26 October 2017
- journal article
- letter
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 377 (17), 1692-1694
- https://doi.org/10.1056/nejmc1711335
Abstract
The study conducted by Jordan et al. (Aug. 3 issue)1 included a low-risk population (2 patients did not have donor-specific antibodies) and pretreatment class I donor-specific antibody levels (the major risk factor for antibody-mediated rejection) were modest (mean [±SD] fluorescence intensity, 5660±2364), yet a high rate of rejection occurred (10 of 22 patients [45%] with donor-specific antibodies). These data raise serious concerns for higher-risk patients.Keywords
This publication has 9 references indexed in Scilit:
- IgG Endopeptidase in Highly Sensitized Patients Undergoing TransplantationThe New England Journal of Medicine, 2017
- A Bacterial IgG-Degrading Enzyme to Unhinge AntibodiesThe New England Journal of Medicine, 2017
- Casting a smaller net into a bigger donor pool: A single center’s experience with the new kidney allocation systemHuman Immunology, 2017
- Changes in Deceased Donor Kidney Transplantation One Year After KAS ImplementationAmerican Journal of Transplantation, 2016
- HLA Class II Antibody Activation of Endothelial Cells Promotes Th17 and Disrupts Regulatory T Lymphocyte ExpansionAmerican Journal of Transplantation, 2015
- The perfect storm: HLA antibodies, complement, FcγRs, and endothelium in transplant rejectionTrends in Molecular Medicine, 2015
- New National Allocation Policy for Deceased Donor Kidneys in the United States and Possible Effect on Patient OutcomesJournal of the American Society of Nephrology, 2014
- Therapeutic Cleavage of Anti–Aquaporin-4 Autoantibody in Neuromyelitis Optica by an IgG-Selective ProteinaseMolecular Pharmacology, 2013
- OKT3 F(ABʼ)2 FRAGMENTS—RETENTION OF THE IMMUNOSUPPRESSIVE PROPERTIES OF WHOLE ANTIBODY WITH MARKED REDUCTION IN T CELL ACTIVATION AND LYMPHOKINE RELEASETransplantation, 1991