Sulfamethoxazole is an antibiotic, which inhibits the bacteria by interfering in its folic acid synthesis mechanism. The objective of this study was to analyze the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of sulfamethoxazole by using modern analytical techniques. The sulfamethoxazole sample was classified as a control and treated samples. The control sample did not receive the Biofield Treatment, while the treated sample received the Biofield Treatment remotely by a renowned Biofield Energy Healer, Dahryn Trivedi. The particle sizes of the treated sample were significantly reduced by 7.99% (d10), 3.05% (d50), 3.80% (d90), and 3.03%{D(4,3)}; whereas, the specific surface area of the particles was increased by 5.19% in the treated sample compared to the control sample. The PXRD peak intensities and crystallite sizes were altered ranging from -70.86% to 52.36% and -6.01% to 75.34%, respectively; whereas the average crystallite size was significantly increased by 27.28% in the treated sulfamethoxazole compared with the control sample. The sample residual amount and maximum thermal degradation temperature were increased by 2.13% and 4.21%, respectively, in the treated sample compared to the control sample. The decomposition temperature and latent heat of decomposition were increased by 3.26% and 19.36%, respectively, in the treated sample compared to the untreated sample. The Biofield Treated sulfamethoxazole might convert to a novel polymorph of the drug, with reduced particle size, increased surface area, and improved thermal stability. This can be helpful in improving the solubility, bioavailability, and stability of the sulfamethoxazole and would be more efficacious for the treatment of infections in the ear, urinary tract infections, traveler’s diarrhoea, bronchitis, shigellosis, and pneumonia, etc.