Clinicopathological evaluation of patients with rippled pattern pigmentation of the skin: A single‐center study
- 19 February 2020
- journal article
- research article
- Published by Hindawi Limited in Dermatologic Therapy
- Vol. 33 (3), e13278
- https://doi.org/10.1111/dth.13278
Abstract
The aim of the present study was to investigate the clinical association between rippled pattern pigmentation and the positivity of histopathological analysis for amyloid. A total of 50 patients (90% women) with rippled pattern pigmentation referring to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, in 2015 participated in this study. Two biopsies were performed for all the cases from the most frequently affected sites. The specimens were evaluated for amyloid deposits with Haematoxylin‐eosin (H&E), Congo red (CR), and crystal violet (CV) stains. The upper back was the most frequently affected area in the patients. Family history (28%), atopy (14%), pruritus as a common finding (86%), and history of friction (54%) were positive. The prevalence of disease was higher in patients with skin photo type 3. Amyloid deposit was not detected in most patients by these stains. No statistically significant difference was found between the amyloid positive cases stained with H&E, CR and CV (P‐value>0.05). Only the difference in positive results between biopsy number 2 and the total biopsy (1&2) was significant (p‐value<0.05). In conclusion, it seems that it is useful to increase the number of biopsies and other more sensitive staining methods to detect small focal amyloid deposits.Keywords
Funding Information
- Shiraz University of Medical Sciences (94‐01‐01‐10203)
This publication has 24 references indexed in Scilit:
- Primary cutaneous amyloidosis: A clinico-pathological study with emphasis on polarized microscopyIndian Journal of Pathology and Microbiology, 2012
- Study on epidemiology of cutaneous amyloidosis in northern India and effectiveness of dimethylsulphoxide in cutaneous amyloidosisIndian Dermatology Online Journal, 2012
- A clinico-epidemiological study of macular amyloidosis from North IndiaIndian Journal of Dermatology, 2012
- Linear macular amyloidosisJournal of the European Academy of Dermatology and Venereology, 2009
- Macular amyloidosis presenting in an incontinentia pigmenti–like pattern with subepidermal blister formationJournal of the European Academy of Dermatology and Venereology, 2007
- Prevalence of macular amyloidosis in north IranIndian Journal of Dermatology, 2007
- A comparative study of two Congo red stains for the detection of primary cutaneous amyloidosisJournal of the American Academy of Dermatology, 2006
- Cytokeratin expression in lichen amyloidosus and macular amyloidosisJournal of the European Academy of Dermatology and Venereology, 2004
- Diffuse primary cutaneous amyloidosisBritish Journal of Dermatology, 1992
- Amyloid and amyloidosisJournal of the American Academy of Dermatology, 1988