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Amyloid beta peptides electrochemistry: A review

Ana-Maria Chiorcea-Paquim,
Published: 15 September 2021

Abstract: Alzheimer disease is a progressive age-related neurodegenerative disorder estimated to affect up to 107 million people by 2050, its pathology being associated with the dysfunction of amyloid β (Aβ) peptide mechanism, among others. Electrochemical methods were successfully applied for Aβ electrochemical characterisation, and have received increased attention in Aβ research. This review discusses the recent advances on the direct electrochemical detection of Aβ redox mechanisms, fibrilization, and interaction with metal ions, based on the electrochemical detection of the Aβ’s , and amino acid residues oxidation peaks.
Keywords: Alzheimer’s disease (AD) / Amyloid beta (Aβ) / fibrilization / aggregation / adsorption / oxidation / voltammetry / AD biomarker

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