Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy
Top Cited Papers
- 17 July 2019
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Drug Metabolism
- Vol. 20 (6), 416-429
- https://doi.org/10.2174/1389200219666180918111528
Abstract
Background: Nanotechnology is gaining significant attention worldwide for cancer treatment. Nanobiotechnology encourages the combination of diagnostics with therapeutics, which is a vital component of a customized way to deal with the malignancy. Nanoparticles are being used as Nanomedicine which participates in diagnosis and treatment of various diseases including cancer. The unique characteristic of Nanomedicine i.e. their high surface to volume ratio enables them to tie, absorb, and convey small biomolecule like DNA, RNA, drugs, proteins, and other molecules to targeted site and thus enhances the efficacy of therapeutic agents.Objective: The objective of the present article is to provide an insight of several aspect of nanotechnology in cancer therapeutics such as various nanomaterials as drug vehicle, drug release strategies and role of nanotechnology in cancer therapy.Methods: We performed an extensive search on bibliographic database for research article on nanotechnology and cancer therapeutics and further compiled the necessary information from various articles into the present article.Results: Cancer nanotechnology confers a unique technology against cancer through early diagnosis, prevention, personalized therapy by utilizing nanoparticles and quantum dots.Nano-biotechnology plays an important role in the discovery of cancer biomarkers. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires etc. have been developed as a carrier of biomolecules that can detect cancer biomarkers. Nanoparticle assisted cancer detection and monitoring involves biomolecules like proteins, antibody fragments, DNA fragments, and RNA fragments as the base of cancer biomarkers.Conclusion: This review highlights various approaches of cancer nanotechnology in the advancement of cancer therapy.Keywords
This publication has 124 references indexed in Scilit:
- Liposomal Doxorubicin in the Treatment of Breast Cancer Patients: A ReviewJournal of Drug Delivery, 2013
- Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristineCancer Chemotherapy and Pharmacology, 2012
- Responsive Theranostic Systems: Integration of Diagnostic Imaging Agents and Responsive Controlled Release Drug Delivery CarriersAccounts of Chemical Research, 2011
- Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecanJournal of Controlled Release, 2011
- The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticlesBiomaterials, 2011
- Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered ReleasePharmaceutical Research, 2010
- A self-assembling nanoparticle for paclitaxel delivery in ovarian cancerBiomaterials, 2009
- Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug DeliveryACS Nano, 2009
- Formulation of functionalized PLGA–PEG nanoparticles for in vivo targeted drug deliveryBiomaterials, 2007
- pH-Sensitive Photoluminescence of CdSe/ZnSe/ZnS Quantum Dots in Human Ovarian Cancer CellsThe Journal of Physical Chemistry C, 2007