Reconfiguration of Amplitude Driven Dominant Coupling Modes (DoCM) mediated by α-band in Adolescents with Schizophrenia Spectrum Disorders
Preprint
- 5 June 2020
- preprint
- research article
- Published by Cold Spring Harbor Laboratory
Abstract
Electroencephalography (EEG) based biomarkers have been shown to correlated with the presence of psychotic disorders. Increased delta and decreased alpha power in psychosis indicate an abnormal arousal state. We investigated brain activity across the basic EEG frequencies and also dynamic functional connectivity of both intra and cross-frequency coupling that could reveal a neurophysiological biomarker linked to an aberrant modulating role of alpha frequency in adolescents with schizophrenia spectrum disorders (SSDs).A dynamic functional connectivity graph (DFCG) has been estimated using the imaginary part of phase lag value (iPLV) and correlation of the envelope (corrEnv). We analyzed DFCG profiles of electroencephalographic resting state (eyes closed) recordings of healthy controls (HC) (n=39) and SSDs subjects (n=45) in basic frequency bands {δ,θ,α1,α2,β1,β2,γ}. In our analysis, we incorporated both intra and cross-frequency coupling modes. Adopting our recent Dominant Coupling Mode (DoCM) model leads to the construction of an integrated DFCG (iDFCG) that encapsulates the functional strength and the DoCM of every pair of brain areas.We revealed significantly higher ratios of delta/alpha1,2 power spectrum in SSDs subjects versus HC. The probability distribution (PD) of amplitude driven DoCM mediated by alpha frequency differentiated SSDs from HC with absolute accuracy (100%). The network Flexibility Index (FI) was significantly lower for subjects with SSDs compared to the HC group.Our analysis supports a central role of alpha frequency alterations in the neurophysiological mechanisms of SSDs. Currents findings open up new diagnostic pathways to clinical detection of SSDs and supports the design of rational neurofeedback training.Highlights: Ratios of delta/alpha1,2 relative power spectrum were significant higher in SSDs subjects compared to HC Probability distribution (PD) of amplitude driven DoCM mediated by alpha frequency differentiated SSDs from HC with 100% Network Flexibility index (FI) was significant lower for subjects with SSDs compared to HC group.Keywords
This publication has 87 references indexed in Scilit:
- Nicotinic Mechanisms in the Treatment of Psychotic Disorders: A Focus on the α7 Nicotinic ReceptorPublished by Springer Science and Business Media LLC ,2012
- Clinical Symptoms and Alpha Band Resting-State Functional Connectivity Imaging in Patients With Schizophrenia: Implications for Novel Approaches to TreatmentBiological Psychiatry, 2011
- Schizophrenia as a disorder of disconnectivityArchiv Fur Psychiatrie Und Nervenkrankheiten, 2011
- Reassessment of the structural basis of the ascending arousal systemJournal of Comparative Neurology, 2010
- The functional role of cross-frequency couplingTrends in Cognitive Sciences, 2010
- A Neural Coding Scheme Formed by the Combined Function of Gamma and Theta OscillationsSchizophrenia Bulletin, 2008
- A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness–persistence–impairment model of psychotic disorderPsychological Medicine, 2008
- Psychosis: Atypical limbic epilepsy versus limbic hyperexcitability with onset at puberty?Epilepsy & Behavior, 2007
- Spontaneous neuronal activity distinguishes human dorsal and ventral attention systemsProceedings of the National Academy of Sciences of the United States of America, 2006
- EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysisBrain Research Reviews, 1999