Nanoscale Metal–Organic Frameworks Stabilize Bacteriochlorins for Type I and Type II Photodynamic Therapy
- 4 April 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 142 (16), 7334-7339
- https://doi.org/10.1021/jacs.0c02129
Abstract
Herein we report the design of a bacteriochlorin-based nanoscale metal-organic framework, Zr-TBB, for highly effective photodynamic therapy via both type I and type II mechanisms. The framework of Zr-TBB stabilizes 5,10,15,20-tetra(p-benzoato)bacteriochlorin (TBB) ligands toward oxygen and light via geometrical constraint. Upon 740 nm light irradiation, Zr-TBB efficiently generates various reactive oxygen species, including singlet oxygen, superoxide anion, hydrogen peroxide and hydroxyl radicals to afford superb antitumor efficacy on mouse models of breast and colon cancers with cure rates of 40% and 60%, respectively.Funding Information
- Division of Chemistry (CHE-1834750)
- National Cancer Institute (P30 CA014599, U01-CA198989)
- Division of Materials Research
This publication has 36 references indexed in Scilit:
- The Chemistry and Applications of Metal-Organic FrameworksScience, 2013
- Stable Synthetic Bacteriochlorins for Photodynamic Therapy: Role of Dicyano Peripheral Groups, Central Metal Substitution (2H, Zn, Pd), and Cremophor EL DeliveryChemMedChem, 2012
- Stable Synthetic Cationic Bacteriochlorins as Selective Antimicrobial PhotosensitizersAntimicrobial Agents and Chemotherapy, 2010
- Metal−Organic Frameworks with Functional Pores for Recognition of Small MoleculesAccounts of Chemical Research, 2010
- Activatable Photosensitizers for Imaging and TherapyChemical Reviews, 2010
- The pervasive chemistry of metal–organic frameworksChemical Society Reviews, 2009
- Photodynamic therapy for cancerNature Reviews Cancer, 2003
- Synthesis, Photophysical Properties, in Vivo Photosensitizing Efficacy, and Human Serum Albumin Binding Properties of Some Novel BacteriochlorinsJournal of Medicinal Chemistry, 1997
- Theoretical Comparative Study of Free Base Porphyrin, Chlorin, Bacteriochlorin, and Isobacteriochlorin: Evaluation of the Potential Roles of ab Initio Hartree−Fock and Density Functional Theories in Hydroporphyrin ChemistryThe Journal of Physical Chemistry B, 1997
- Intracellular uptake, absorption spectrum and stability of the bacteriochlorin photosensitizer 5,10,15, 20-tetrakis (m-hydroxyphenyl) bacteriochlorin (mTHPBC). Comparison with 5,10,15,20-tetrakis (m-hydroxyphenyl) chlorin (mTHPC)Journal of Photochemistry and Photobiology B: Biology, 1997