We would recommend this article because it convincingly shows that the cyclic GMP-AMP synthase (cGAS) signalling pathway affects cellular senescence. The authors figure out that the activation of the cGAS-STING pathway occurs through the recognition of cytosolic chromatin fragments in senescent cells arising due to the decreased expression of the nuclear envelope component lamin B1. The activated cGAS-STING pathway then in turn provokes the secretion of a variety of senescence-associated secretory phenotype (SASP) factors, resulting in paracrine senescence. Given the fact that the authors pointed out a role for cGAS in senescence induction in vitro as well as in vivo, the cGAS-STING pathway may serve as anticancer and antitumor mechanism protecting patients against uncontrolled growth and metastasis of cancer cells.