DYNAMICS OF MORPHOMETRIC INDICATORS OF GINGIVAL MUCOUS MEMBRANE COMPONENTS OF RATS IN THE LATE TERMS OF CHRONIC OPIOID INFLUENCE

Abstract

The aim of this study was to examine the morphometric parameters of the thickness of the epithelial plate of the gingival mucosa, the height of the connective tissue papillae and the diameter of the lumen of hemomicrovascular white rats in the dynamics after eight, ten and twelve weeks of chronic opioid exposure. Experimental studies were performed on white male rats of reproductive age. For twelve weeks, rats were injected intramuscularly with the opioid analgesic nalbuphine at increasing average therapeutic doses of 0.212 to 0.3 mg/kg body weight. Fragments of rat jaws were used for histological and morphometric studies. Based on the analysis of the obtained morphometric parameters of the studied components of the gums, it was found that in the late stages of chronic opioid exposure there was a significant decrease in epithelial thickness and connective tissue papillae and a significant increase in the lumen diameter of hemomicrocirculatory progression of inflammatory-dystrophic changes in periodontal tissues.