Rheological, mechanical, and bioadhesive behavior of hydrogels to optimize skin delivery systems
- 11 October 2012
- journal article
- research article
- Published by Taylor & Francis Ltd in Drug Development and Industrial Pharmacy
- Vol. 39 (11), 1750-1757
- https://doi.org/10.3109/03639045.2012.734510
Abstract
Background: Hydrogels are widely used for cutaneous formulations; thereby comparing the bioadhesive properties of polymers with a view to prolong the residence time of topical drugs on the skin would be very useful to design novel topical drug delivery systems. Aim: The objective of this study was to correlate data from rheological studies and texture profile analysis, with bioadhesion on the skin. Methods: Polyacrylic acid polymers used were carbomer homopolymer type A (C971) and type B (C974), and polycarbophil (PP) dispersed in water at various concentrations (0.1, 0.5, 1.0, 1.5, 2.0, 3.0, 5.0%, w/v). Rheological, texture, and bioadhesive properties were determined to compare the hydrogels. Results: Rheological analysis showed that all samples exhibited pseudoplastic behavior with thixotropy. Texture profile analysis showed that compressibility, hardness, and adhesiveness of the hydrogels were dependent on the polymer concentration, and the cohesion values were high. Bioadhesion of C974 and PP at 0.5 and 2% was of the same magnitude, while all samples of C971 had lower values. The bioadhesion of 5% C974 was the highest, while that 5% PP was lower, possibly because PP showed the greatest hardness and this rigidity may decrease the interaction of the polymer with the skin. Conclusion: A comprehensive comparative rheological and textural analyses of several polymers for topical systems were undertaken in terms of their bioadhesion. Therefore, it is possible to conclude that these polymers can be used for optimization of drug delivery systems on the skin.Keywords
This publication has 31 references indexed in Scilit:
- Swelling behavior and biocompatibility of Carbopol‐containing superporous hydrogel compositesJournal of Applied Polymer Science, 2007
- Microrheology and structure of a yield-stress polymer gelPhysical Review E, 2006
- Synthesis, equilibrium swelling, kinetics, permeability and applications of environmentally responsive gelsPublished by Springer Science and Business Media LLC ,2005
- Hydrogels as separation agentsPublished by Springer Science and Business Media LLC ,2005
- The Influence of Cosolvent Polarity on the Flow Properties of Hydroalcoholic Gels. Empirical ModelsCHEMICAL & PHARMACEUTICAL BULLETIN, 2005
- Rheological, mucoadhesive and release properties of Carbopol gels in hydrophilic cosolventsInternational Journal of Pharmaceutics, 2004
- Hydrogels for biomedical applicationsAdvanced Drug Delivery Reviews, 2001
- The use of bioadhesives in targeted delivery within the gastrointestinal tractAdvanced Drug Delivery Reviews, 1993
- Volume phase transition and related phenomena of polymer gelsPublished by Springer Science and Business Media LLC ,1993
- The use of dilute solution viscometry to characterize the network properties of carbopol microgelsColloid and Polymer Science, 1992