Neuromodulatory effect of plant metabolites
Open Access
- 26 July 2022
- journal article
- Published by Etflin in Sciences of Phytochemistry
- Vol. 1 (1), 47-69
- https://doi.org/10.58920/sciphy01010047
Abstract
Neurological disorders (NDDs) are diseases that affect the central and peripheral nervous systems. Gradual malfunction and destruction of the neurons or the nerve cells characterize them. Every year, NDDs affect millions of people worldwide. Over the years, several neuromodulatory techniques have been introduced to improve the quality of life for those affected by NDDs. NDDs are chronic and incurable conditions, however, bioactive substances derived from medicinal plants have emerged as the greatest choice for their prevention and treatment. Literature evidences several benefits of plant metabolites as alternative medicines for the prevention and treatment of NDDs. Numerous investigations have shown plant metabolites to possess beneficial biological effects because of their qualities, which include but are not limited to anti-inflammatory, antioxidant, and neuroprotective actions. Practices of folk medicine and several studies have also guided many phytopharmacological interventions toward the treatment of NDDs. This review aims to highlight secondary metabolites (alkaloids, flavonoids, steroids, terpenoids) of plants with neuroprotective action that could potentially play an important role in the prevention and management of NDDs.Keywords
This publication has 187 references indexed in Scilit:
- In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effectsBMC Complementary and Alternative Medicine, 2013
- Berberine Promotes Axonal Regeneration in Injured Nerves of the Peripheral Nervous SystemJournal of Medicinal Food, 2012
- Clinical progression in Parkinson disease and the neurobiology of axonsAnnals of Neurology, 2010
- Apigenin: A Promising Molecule for Cancer PreventionPharmaceutical Research, 2010
- Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF‐I receptor signalling pathwayBritish Journal of Pharmacology, 2009
- Protective actions of sex steroid hormones in Alzheimer’s diseaseFrontiers in Neuroendocrinology, 2009
- Flavonoid‐mediated presenilin‐1 phosphorylation reduces Alzheimer's disease β‐amyloid productionJournal of Cellular and Molecular Medicine, 2009
- Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated MacrophagesMediators of Inflammation, 2007
- NEUROPROTECTIVE EFFECTS OF CURCUMINPublished by Springer Science and Business Media LLC ,2007
- Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptorBritish Journal of Pharmacology, 2006