MYD88 L265P Somatic Mutation
Open Access
- 1 September 2013
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 140 (3), 387-394
- https://doi.org/10.1309/ajcp10zclfzgyzip
Abstract
To examine the usefulness of the MYD88 L265P somatic mutation in identifying cases of lymphoplasmacytic lymphoma (LPL) from other lymphoplasmacytic neoplasms in bone marrow biopsy specimens. We studied 64 bone marrow biopsy specimens with involvement by various small B-cell lymphomas or plasma cell myeloma. The MYD88 L265P somatic mutation was present in 13/13 cases of LPL, 1/13 cases of hairy cell leukemia, and absent in the other mature B-cell neoplasms tested. A test set of diagnostically challenging bone marrow cases with lymphoplasmacytoid morphology (B-cell lymphoma, not otherwise specified) was selected for additional review and reclassified, without knowledge of the MYD88 L265P status. Of those 16 cases, 7 were positive for MYD88, including 4/4 cases that were reclassified as LPL during the review. Although not entirely specific, MYD88 L265P is a useful adjunct for bone marrow diagnosis in separating LPL from other small B-cell lymphomas and plasma cell myeloma.Keywords
This publication has 37 references indexed in Scilit:
- MYD88 L265P Somatic Mutation in Waldenström's MacroglobulinemiaThe New England Journal of Medicine, 2012
- Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalitiesLaboratory Investigation, 2012
- Clinical, Immunophenotypic, and Genetic Characterization of Small Lymphocyte–Like Plasma Cell MyelomaAmerican Journal of Clinical Pathology, 2010
- Immunohistochemical Analysis Identifies Two Cyclin D1+ Subsets of Plasma Cell Myeloma, Each Associated With Favorable SurvivalAmerican Journal of Clinical Pathology, 2006
- Lymphoid Neoplasms Associated With IgM ParaproteinAmerican Journal of Clinical Pathology, 2005
- Despite apparent morphologic and immunophenotypic heterogeneity, Waldenstrom's macroglobulinemia is consistently composed of cells along a morphologic continuum of small lymphocytes, plasmacytoid lymphocytes, and plasma cellsSeminars in Oncology, 2003
- Waldenström macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletionsBlood, 2002
- Cytogenetic Findings in Lymphoplasmacytic Lymphoma /Waldenström MacroglobulinemiaAmerican Journal of Clinical Pathology, 2001
- Genomic Aberrations and Survival in Chronic Lymphocytic LeukemiaThe New England Journal of Medicine, 2000
- Bone Marrow Histology in Waldenström's MacroglobulinaemiaScandinavian Journal of Haematology, 1983