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Physico-Chemical and Microbiological Study for the Stability of Phenytoin Sodium Extemporaneously Compounded Suspension in Saudi Arabia Hospitals

Syed Ata Ur Rahman, Abdullah Alsaedi, Abdulelah Alhusayni, Abdulmalik Alqurshi, Sameh Ahmed, Yaser M. Alahmadi, Alaa Omer M. Abdullaal, Badr Ahmed A. Taher, El-Sayed E. Habib
Pharmacology & Pharmacy , Volume 12, pp 1-9; doi:10.4236/pp.2021.121001

Abstract: Epilepsy is a chronic and the fourth most common neurological disorder which affects people of all age groups. Recently research and awareness on epilepsy-related deaths have rapidly grown over the past two decades. Many previous studies are attributed to the guidelines that apprise health care professionals in handling these deaths, but there is a relative scarcity of information accessible for clinicians and pharmacists who are responsible for manufacturing or preparing the extemporaneous anti-epileptic suspensions in the hospitals. Mostly in partial seizures, phenytoin is one of the first-choice drugs. In Saudi Arabian hospitals, the extemporaneous preparation of phenytoin suspension is common, but the hot climatic weather in Saudi Arabia possesses stability problems that should be tackled as the prepared suspension should pass all the stability tests to ensure uniform dosage of the extemporaneous formulation. In the current study, the commercial capsules were used to prepare the oral phenytoin sodium extemporaneous suspension. The physical, chemical and microbiological stability of phenytoin sodium suspension is analyzed at various temperatures.
Keywords: epilepsy / physical stability / Chemical stability / phenytoin / Extemporaneous Preparation

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