The neuro-toxin MPTP does not prevent reproduction in marmosets
Open Access
- 26 April 2019
- journal article
- Published by F1000 Research Ltd in MNI Open Research
Abstract
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neuro-toxin that has been employed to model Parkinson’s disease in non-human primates for over 3 decades. Despite its use for such a long period, little is known about the effects of MPTP on reproductive function. Here, we report the case of a male marmoset which was able to procreate 1.5 year after having been administered the toxin. We also report on 1 male and 1 female MPTP-lesioned marmosets which produced babies after being housed together for 5 years. These cases suggests that MPTP may not interfere with marmoset reproductive function or that if it does, it may be for a limited period of time.Keywords
Funding Information
- Natural Sciences and Engineering Research Council of Canada
- Parkinson Canada
- Fonds de Recherche du Québec - Santé
- Michael J. Fox Foundation for Parkinson's Research
- Weston Brain Institute
- Montreal Neurological Institute
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