Biological perspectives and current biofabrication strategies in osteochondral tissue engineering
Open Access
- 9 July 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Biomanufacturing Reviews
- Vol. 5 (1), 1-24
- https://doi.org/10.1007/s40898-020-00008-y
Abstract
Articular cartilage and the underlying subchondral bone are crucial in human movement and when damaged through disease or trauma impacts severely on quality of life. Cartilage has a limited regenerative capacity due to its avascular composition and current therapeutic interventions have limited efficacy. With a rapidly ageing population globally, the numbers of patients requiring therapy for osteochondral disorders is rising, leading to increasing pressures on healthcare systems. Research into novel therapies using tissue engineering has become a priority. However, rational design of biomimetic and clinically effective tissue constructs requires basic understanding of osteochondral biological composition, structure, and mechanical properties. Furthermore, consideration of material design, scaffold architecture, and biofabrication strategies, is needed to assist in the development of tissue engineering therapies enabling successful translation into the clinical arena. This review provides a starting point for any researcher investigating tissue engineering for osteochondral applications. An overview of biological properties of osteochondral tissue, current clinical practices, the role of tissue engineering and biofabrication, and key challenges associated with new treatments is provided. Developing precisely engineered tissue constructs with mechanical and phenotypic stability is the goal. Future work should focus on multi-stimulatory environments, long-term studies to determine phenotypic alterations and tissue formation, and the development of novel bioreactor systems that can more accurately resemble the in vivo environment.Keywords
Funding Information
- Engineering and Physical Sciences Research Council (EP/L014904/1)
- Fundação para a Ciência e a Tecnologia (PTDC/MEC-GIN/29232/2017, 0245_IBEROS_1_E)
This publication has 211 references indexed in Scilit:
- Induced Collagen Cross-Links Enhance Cartilage IntegrationPLOS ONE, 2013
- Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic ApproachesArthritis, 2012
- A Comparison of the Functionality andIn VivoPhenotypic Stability of Cartilaginous Tissues Engineered from Different Stem Cell SourcesTissue Engineering, Part A, 2012
- The use of osteochondral allografts in the management of cartilage defectsCurrent Reviews in Musculoskeletal Medicine, 2012
- The Role of Growth Factors in Cartilage RepairClinical Orthopaedics and Related Research, 2011
- Physical Stimulation of Chondrogenic Cells In Vitro: A ReviewClinical Orthopaedics and Related Research, 2011
- The Basic Science of Articular Cartilage: Structure, Composition, and FunctionSports Health: a Multidisciplinary Approach, 2009
- Interleukin‐1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF‐κB–dependent pathwaysArthritis & Rheumatism, 2009
- Revision Rates after Primary Hip and Knee Replacement in England between 2003 and 2006PLoS Medicine, 2008
- The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilageArthritis & Rheumatism, 2004