Understanding the roles of natural drivers in greenhouse gas (GHG) emissions of arable fields is crucial for adequate agricultural management. This study investigated the combined effect of two tillage treatments (NT - no-tillage; CT - tillage with mouldboard ploughing) and environmental (air pressure, air temperature) and soil factors (total organic carbon, gravimetric water content and soil penetration resistance) on soil carbon dioxide (CO2) emissions in maize in 2020 and 2021. The soil tubes required for the laboratory measurement were derived from three different altitudes of the two differently cultivated fields from Fejér county, Hungary. The typical soil type was Chernozem in both fields. At the time of soil sampling, soil penetration resistance was measured with a 06.15SA Penetrologger in 10 repetitions. To preserve the moisture content of the soil columns during the investigation, moisture replenishment was performed equal to the degree of weekly theoretical evapotranspiration. Emissions measurements of soil columns were performed by close chamber technique for five weeks from sampling, 15 times, in 3 repetitions in laboratory conditions. The data were evaluated by two-way ANOVA, followed by the Tukey HSD multiple comparison test and two-tailed Student’s T-test at a significance level of p2=0.92 at a significance level of p=0.05) in 2020, while the combined effect of moisture content and air temperature in the no-tillage system (adjusted R2=0.79 at a significance level of p=0.085) has the most significant effect on soil CO2 emissions in 2020. In 2021, the air temperature for the tillage system (adjusted R2=0.74 at a significance level of p=0.05) and the combined effect of air temperature and pressure for no-tillage systems (adjusted R2=0.69 at a significance level of p=0.1) played an important role in soil CO2 emissions. These observations highlight that different soil and environmental factors of different tillage significantly impact the soil carbon dioxide emissions in different years.