Recent progress in the asymmetric Mannich reaction
Open Access
- 30 June 2012
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 3 (2), 258-266
- https://doi.org/10.5155/eurjchem.3.2.258-266.536
Abstract
The asymmetric Mannich reaction is one of the most useful carbon-carbon bond forming reactions for the synthesis of chiral molecules containing nitrogen. The resulting β-amino carbonyl compounds are valuable synthons in the preparation of many natural products with useful biological properties. In recent years, asymmetric Mannich processes have increasingly been reported and used in a rapidly growing number of applications. This review provides an overview of the recent history of the applications of various catalytic systems in asymmetric Mannich reaction, including metal-based asymmetric organocatalysis, asymmetric organocatalysis, other chiral catalysis and no chiral catalysis systems.Keywords
This publication has 58 references indexed in Scilit:
- Catalytic asymmetric direct Mannich reaction: a powerful tool for the synthesis of α,β-diamino acidsChemical Society Reviews, 2009
- Direct Catalytic Asymmetric Mannich-Type Reaction of β-Keto Phosphonate Using a Dinuclear Ni2−Schiff Base ComplexOrganic Letters, 2008
- Organocatalysed asymmetric Mannich reactionsChemical Society Reviews, 2007
- Asymmetric organocatalysisTetrahedron, 2007
- The Direct Catalytic Asymmetric Mannich ReactionAccounts of Chemical Research, 2004
- Recent Developments in the Catalytic Asymmetric Synthesis of α‐ and β‐Amino AcidsAngewandte Chemie, 2003
- Recent advances in the stereoselective synthesis of β-amino acidsTetrahedron, 2002
- Catalytic Enantioselective Addition to IminesChemical Reviews, 1999
- N,N-Phthaloylamino Acids as Chiral Auxiliaries in Asymmetric Mannich-Type ReactionsAngewandte Chemie, 1999
- Modern Variants of the Mannich ReactionAngewandte Chemie, 1998