A conditional approach for the receiver operating characteristic curve construction to evaluate diagnostic test performance in a family-matched case–control design
- 7 April 2021
- journal article
- research article
- Published by SAGE Publications in Statistical Methods in Medical Research
- Vol. 30 (5), 1249-1272
- https://doi.org/10.1177/0962280221995956
Abstract
Receiver operating characteristic curves are widely used in medical research to illustrate biomarker performance in binary classification, particularly with respect to disease or health status. Study designs that include related subjects, such as siblings, usually have common environmental or genetic factors giving rise to correlated biomarker data. The design could be used to improve detection of biomarkers informative of increased risk, allowing initiation of treatment to stop or slow disease progression. Available methods for receiver operating characteristic construction do not take advantage of correlation inherent in this design to improve biomarker performance. This paper will briefly review some developed methods for receiver operating characteristic curve estimation in settings with correlated data from case–control designs and will discuss the limitations of current methods for analyzing correlated familial paired data. An alternative approach using conditional receiver operating characteristic curves will be demonstrated. The proposed approach will use information about correlation among biomarker values, producing conditional receiver operating characteristic curves that evaluate the ability of a biomarker to discriminate between affected and unaffected subjects in a familial paired design.Funding Information
- Juvenile Diabetes Research Foundation United States of America (NIAID 5R01AI123258)
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