CAN PROLACTIN BE A MARKER FOR DEVELOPMENT AND PROGRESSION OF PCOS?

Abstract

Background: Polycystic ovarian syndrome has been one of a major public health problem. It causes multifactorial in etiology such as menstrual dysfunction, hyperandrogenism, hirsutism, insulin resistance, dyslipidemia and obesity which increased risk of diabetes mellitus and cardiovascular disease. Prolactin has been reported as a potent lipogenic and diabetogenic factor, that affecting energy balance and fuel metabolism. The present study was designed to assess serum prolactin and insulin resistance in PCOS women and to compare them with healthy women as controls. Material And Methods: A comparative study including 50 women newly diagnosed as PCOS and 50 healthy women as controls was conducted. The age group for the study was 18-35 years. Fasting blood samples were drawn to assess serum prolactin, serum insulin and fasting blood sugar. Insulin resistance was calculated by homeostasis model assessment. Results: A signicant increase in fasting serum insulin (p<0.001) and HOMA – IR (p<0.001) were found in patients with PCOS in comparison with controls. Prolactin and FPG were found elevated in the PCOS women and were statistically signicant. Conclusions: The current study provides further evidence that signicantly higher fasting insulin and HOMA in PCOS group indicates presence of IR. IR in PCOS group may have a potential role in the prediction of dysglycemic disease in women with PCOS. This study found signicant correlation between serum prolactin and serum insulin