Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma
Open Access
- 24 November 2020
- journal article
- research article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2020, 1-15
- https://doi.org/10.1155/2020/8024138
Abstract
Lung adenocarcinoma (LUAD) is a major pathological type of lung cancer. Understanding the mechanism of LUAD at the molecular level is important for a clinical decision. In this study, we use bioinformatic analysis to explore the prognostic value of P4HA1 in lung adenocarcinoma (LUAD) and the relationship with prognosis and tumor-infiltrating immune cells (TIICs). The results showed that the expression of P4HA1 was significantly higher in tumor tissues than in normal tissues for LUAD patients. Upregulated P4HA1 was related to stage and T classification. Kaplan-Meier analysis indicated that upregulation of P4HA1 was significantly related to worse overall survival (OS). Univariate and multivariate Cox analysis indicated P4HA1 remained to be an independent prognostic factor. GSEA showed that several cancer-related and immune-related signaling pathways exhibited prominently differential enrichment in P4HA1-high expression phenotype. In addition, the expression of P4HA1 was significantly correlated with proportion of several TIICs, particularly B cells and CD4+ T cells. In conclusion, our study confirmed that P4HA1 is a promising biomarker of poor prognosis and relates to immune infiltrates in LUAD.Funding Information
- National Natural Science Foundation of China (81773231, 81572960)
This publication has 61 references indexed in Scilit:
- Targeting the Tumor Microenvironment for Cancer TherapyClinical Chemistry, 2013
- The immune contexture in human tumours: impact on clinical outcomeNature Reviews Cancer, 2012
- Prolyl 4-hydroxylaseCritical Reviews in Biochemistry and Molecular Biology, 2010
- Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinomaDisease Models & Mechanisms, 2010
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin SignalingCell, 2009
- CXCL13 expression in the gut promotes accumulation of IL-22-producing lymphoid tissue-inducer cells, and formation of isolated lymphoid folliclesMucosal Immunology, 2009
- Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targetsAnnals of Medicine, 2008
- Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProceedings of the National Academy of Sciences of the United States of America, 2005
- Collagens, modifying enzymes and their mutations in humans, flies and wormsTrends in Genetics, 2004
- A Conserved Family of Prolyl-4-Hydroxylases That Modify HIFScience, 2001