The Latest Research Progress of m6A Modification and Its Writers, Erasers, Readers in Infertility: A Review
Open Access
- 10 September 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by “Writer” m6A methyltransferase, removed by “Eraser” m6A demethylase, and recognized by the m6A binding protein, thereby, linking m6A modification with other mRNA pathways. At various stages of the life cycle, m6A modification plays an extremely important role in regulating mRNA splicing, processing, translation, as well as degradation, and is associated with gametogenesis and fertility for both sexes. Normal gametogenesis is a basic guarantee of fertility. Infertility leads to trauma, affects harmony in the family and seriously affects the quality of life. We review the roles and mechanisms of RNA m6A methylation modification in infertility and provide a potential target for infertility treatment, which can be used for drug development.This publication has 132 references indexed in Scilit:
- Mouse primordial germ cells produce cysts that partially fragment prior to meiosisDevelopment, 2013
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse FertilityMolecular Cell, 2013
- The Germline Stem Cell Niche Unit in Mammalian TestesPhysiological Reviews, 2012
- Regulation of entry into gametogenesisPhilosophical Transactions B, 2011
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTONature Chemical Biology, 2011
- The RNA modification database, RNAMDB: 2011 updateNucleic Acids Research, 2010
- Oestrogens and spermatogenesisPhilosophical Transactions B, 2010
- Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell CompartmentScience, 2010
- Global Survey of Protein Expression during Gonadal Sex Determination in MiceMolecular & Cellular Proteomics, 2009
- MODOMICS: a database of RNA modification pathways. 2008 updateNucleic Acids Research, 2008