ABCA1 Variants rs1800977 (C69T) and rs9282541 (R230C) Are Associated with Susceptibility to Type 2 Diabetes
- 24 January 2020
- journal article
- research article
- Published by S. Karger AG in Public Health Genomics
- Vol. 23 (1-2), 20-25
- https://doi.org/10.1159/000505344
Abstract
Objective: Accumulated evidence suggests that ATP-binding cassette A1 transporter (ABCA1) contributes to secreting insulin in pancreatic β-cells and amyloid beta formation. This study aimed to investigate the association between three single nucleotide polymorphisms (SNPs) of ABCA1 and susceptibility to type 2 diabetes mellitus (T2DM) in a Han Chinese population. Methods: A total of 996 T2DM patients and 1,002 controls were included in the study. Three SNPs in the ABCA1 gene, i.e., rs2230806 (R219K), rs1800977 (C69T), and rs9282541 (R230C), were genotyped by SNaPshot. A genotype model, an allele model, a dominant model, and a recessive model were used to assess susceptibility to T2DM. Results: There were significant associations between rs1800977 and T2DM in different genetic models (TT vs. CC, OR = 0.591 [0.446–0.793], p < 0.001; T vs. C, OR = 0.835 [0.735–0.949], p = 0.006; recessive model, OR = 0.583 [0.449–0.756], p < 0.001). There were also significant associations between rs9282541 and T2DM in different genetic models (CT vs. CC, OR = 1.690 [0.807–1.005], p = 0.048; T vs. C, OR = 1.756 [0.694–1.060], p = 0.029; dominant model, OR = 1.735 [0.715–1.034], p = 0.037). Conclusion: Our case-control study showed that the two SNPs rs1800977 and rs9282541 in the ABCA1 gene are significantly associated with susceptibility to T2DM in our Han Chinese population. Study of further mechanisms should be performed before application to clinical therapy.Keywords
This publication has 28 references indexed in Scilit:
- Type 2 diabetes mellitus and atrial fibrillation: From mechanisms to clinical practiceArchives of Cardiovascular Diseases, 2015
- ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivityJournal of Lipid Research, 2014
- Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse modelsJournal of Lipid Research, 2013
- Investigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitusBiochemia Medica, 2012
- Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin GranulesDiabetes, 2011
- A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native AmericansHuman Molecular Genetics, 2010
- Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanismBiochemical Pharmacology, 2008
- Evidence for Disease Control with Erlotinib after Gefitinib Failure in Typical Gefitinib-Sensitive Asian Patients with Non-small Cell Lung CancerJournal of Thoracic Oncology, 2008
- Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patientsActa Pharmacologica Sinica, 2008
- β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatmentNature Medicine, 2007