FRET‐Integrated Polymer Brushes for Spatially Resolved Sensing of Changes in Polymer Conformation
Open Access
- 12 May 2021
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 60 (30), 16600-16606
- https://doi.org/10.1002/anie.202104204
Abstract
Polymer brush surfaces that alter their physical properties in response to chemical stimuli have the capacity to be used as new surface‐based sensing materials. For such surfaces, detecting the polymer conformation is key to their sensing capabilities. Herein, we report on FRET‐integrated ultrathin (< 70 nm) polymer brush surfaces that exhibit stimuli‐dependent FRET with changing brush conformation. Poly( N ‐isopropylacrylamide) polymers were chosen due their exceptional sensitivity to liquid mixture compositions and their ability to be assembled into well‐defined polymer brushes. The brush transitions were used to optically sense changes in liquid mixture compositions with high spatial resolution (10s of μm), where the FRET‐coupling allowed for non‐invasive observation of brush transitions around complex interfaces with real‐time sensing of the liquid environment. Our methods have the potential to be leveraged towards greater surface‐based sensing capabilities at intricate interfaces.Keywords
Funding Information
- Alexander von Humboldt-Stiftung (1205007)
This publication has 37 references indexed in Scilit:
- Co-nonsolvency of PNiPAM at the transition between solvation mechanismsSoft Matter, 2014
- Switchable Friction Using Contacts of Stimulus-Responsive and Nonresponding Swollen Polymer BrushesLangmuir, 2014
- Fluorescent water-soluble responsive polymers site-specifically labeled with FRET dyes possessing pH- and thermo-modulated multicolor fluorescence emissions as dual ratiometric probesJournal of Materials Chemistry, 2011
- Optical Nanosensor Platform Operating in Near-Physiological pH Range via Polymer-Brush-Mediated Plasmon CouplingACS Applied Materials & Interfaces, 2011
- Stimulus-responsive polymer brushes on surfaces: Transduction mechanisms and applicationsProgress in Polymer Science, 2010
- Fabrication of Photoswitchable and Thermotunable Multicolor Fluorescent Hybrid Silica Nanoparticles Coated with Dye-Labeled Poly(N-isopropylacrylamide) BrushesChemistry of Materials, 2009
- A structural definition of polymer brushesJournal of Polymer Science Part A: Polymer Chemistry, 2007
- Fast and Spatially Resolved Environmental Probing Using Stimuli‐Responsive Polymer Layers and Fluorescent NanocrystalsAdvanced Materials, 2006
- Macromolecular anchoring layers for polymer grafting: comparative studyPolymer, 2005
- Reorganization of Binary Polymer Brushes: Reversible Switching of Surface Microstructures and Nanomechanical PropertiesMacromolecules, 2003