Simultaneous Quantitation of Multiple Classes of Organohalogen Compounds in Fish Oils with Direct Sample Introduction Comprehensive Two-Dimensional Gas Chromatography and Time-of-Flight Mass Spectrometry
- 5 March 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 57 (7), 2653-2660
- https://doi.org/10.1021/jf900462p
Abstract
We successfully optimized an analytical method using gel permeation chromatography followed by direct sample introduction comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry to quantify multiple groups of targeted persistent organic pollutants and halogenated natural products (HNPs) simultaneously in fish oil samples. This new method has a wider analytical scope than the traditional approach to use multiple methods to cover each class of compounds. Our analysis revealed that the relatively more volatile and lighter organic compounds, such as polychlorinated biphenyls (PCBs), organochlorine pesticides, and other smaller organohalogen compounds, were still present in two brands of “PCB-free” cod liver oils, albeit at much lower levels than in an untreated commercial sample. Moreover, the less volatile organic compounds, such as polybrominated diphenyl ethers and brominated HNPs, were detected at similar levels in all three cod liver oils. This suggests that the commercial molecular distillation treatment used for removal of organic/inorganic toxic contaminants is only effective for the lighter organic contaminants.This publication has 38 references indexed in Scilit:
- Concentrations of the Sunscreen Agent Benzophenone-3 in Residents of the United States: National Health and Nutrition Examination Survey 2003–2004Environmental Health Perspectives, 2008
- Fish Intake, Contaminants, and Human HealthJAMA, 2006
- Injector‐internal thermal desorption from edible oils performed by programmed temperature vaporizing (PTV) injectionJournal of Separation Science, 2006
- Dioxins and polychlorinated biphenyls (PCBs) in fish oil dietary supplements: Occurrence and human exposure in the UKFood Additives & Contaminants, 2006
- Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreensToxicology and Applied Pharmacology, 2005
- Two Abundant Bioaccumulated Halogenated Compounds Are Natural ProductsScience, 2005
- Dietary Exposure to a Group of Naturally Produced Organohalogens (Halogenated Dimethyl Bipyrroles) via Consumption of Fish and SeafoodJournal of Agricultural and Food Chemistry, 2004
- Global Assessment of Organic Contaminants in Farmed SalmonScience, 2004
- Reproductive and morphological effects of halogenated dimethyl bipyrroles on captive American kestrels (Falco sparverius)Environmental Toxicology and Chemistry, 2003
- Chlorinated anisoles and veratroles in a Canadian river receiving bleached kraft pulp mill effluent. Identification, distribution, and olfactory evaluationEnvironmental Science & Technology, 1993