蛋氨酸是人体必需氨基酸，参与蛋白质和体内多种具有重要功能的生物分子的合成。近年来在多种模式生物中发现限制膳食中蛋氨酸的摄入可延长寿命，促进代谢健康，延缓或改善多种慢性衰老相关疾病的发生发展。本文简要概括了近年来膳食蛋氨酸限制健康促进作用和相关机制的进展，以其对进一步研究和应用提供有益线索。 Methionine is an essential amino acid for human that plays critical roles in the syntheses of many important biological molecules including protein. Recent studies have demonstrated that dietary methionine restriction can prolong lifespan, improve metabolic heath, prevent and postpone the development of some age-related chronic diseases in various model organisms. In this review, we summarized the recent progression of researches regarding the health promotion effects of dietary methionine restriction and the underlying mechanism, and expected to provide clues for further research and application.