According to International Guidelines for Management of Sepsis and Septic Shock 2016, sepsis was defined as life threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major healthcare problems and the incidence increased by year. Septic Shock was defined as subset of sepsis in which underlying circulatory and cellular metabolism abnormalities are profound enough to substantially increase mortality and can be identified with persisting hypotension requiring vasopressors to maintain MAP>65mmHg and having serum lactate level > 2 mmo/L despite adequate volume resuscitation. Intraabdominal infection was reported as contributor to a high mortality rate for infection case in intensive care units. We reported a case of a patient with sepsis and septic shock caused by intraabdominal infection post laparotomy exploration ec gastric perforation. The patient was monitored prospectively, received antibiotics, hemodynamic support and mechanical ventilation support while being treated in the ICU. On the sixth day, the patient was transferred to ward.