SARS-CoV-2 Infection Dynamics in Children and Household Contacts in a Slum in Rio de Janeiro
- 1 July 2021
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 148 (1)
- https://doi.org/10.1542/peds.2021-050182
Abstract
OBJECTIVES To investigate the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a vulnerable population of children and their household contacts. METHODS SARS-CoV-2 reverse transcription polymerase chain reaction assays and coronavirus disease 2019 (COVID-19) immunoglobulin G serology tests were performed in children and their household contacts after enrollment during primary health care clinic visits. Participants were followed prospectively with subsequent specimens collected through household visits in Manguinhos, an impoverished urban slum (a favela) in Rio de Janeiro at 1, 2, and 4 weeks and quarterly post study enrollment. RESULTS Six hundred sixty-seven participants from 259 households were enrolled from May to September 2020. This included 323 children (0-13 years), 54 adolescents (14-19 years), and 290 adults. Forty-five (13.9%) children had positive test results for SARS-CoV-2 polymerase chain reaction. SARS-CoV-2 infection was most frequent in children aged <1 year (25%) and children aged 11 to 13 years (21%). No child had severe COVID-19 symptoms. Asymptomatic infection was more prevalent in children aged = 14 years (74.3% and 51.1%, respectively). All children (n = 45) diagnosed with SARS-CoV-2 infection had an adult contact with evidence of recent infection. CONCLUSIONS In our setting, children do not seem to be the source of SARS-CoV-2 infection and most frequently acquire the virus from adults. Our findings suggest that, in settings such as ours, schools and child care potentially may be reopened safely if adequate COVID-19 mitigation measures are in place and staff are appropriately immunized.This publication has 17 references indexed in Scilit:
- Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19)JAMA Pediatrics, 2020
- SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controlsNature, 2020
- Epidemiology of COVID-19 Among Children in ChinaPEDIATRICS, 2020
- The Role of Children in the Dynamics of Intra Family Coronavirus 2019 Spread in Densely Populated AreaThe Pediatric Infectious Disease Journal, 2020
- School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic reviewThe Lancet Child & Adolescent Health, 2020
- The REDCap consortium: Building an international community of software platform partnersJournal of Biomedical Informatics, 2019
- Influenza Transmission in a Cohort of Households with Children: 2010-2011PLOS ONE, 2013
- Household Transmission of 2009 Pandemic Influenza A (H1N1)Epidemiology, 2012
- Sample Size Estimation in Prevalence StudiesIndian Journal of Pediatrics, 2012
- Studies of the Community and Family: Acute Respiratory Illness and InfectionEpidemiologic Reviews, 1994