Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS-STN: A Combined PET and Neuropsychological Study
Open Access
- 16 May 2022
- journal article
- research article
- Published by MDPI AG in Brain Sciences
- Vol. 12 (5), 654
- https://doi.org/10.3390/brainsci12050654
Abstract
Patients with Parkinson’s disease (PD) often suffer from non-motor symptoms, which may be caused by serotonergic dysfunction. Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non-motor symptoms. The aim of this study is to investigate how the cerebral 5-HT system associates to disturbances in cognition and mood in PD patients with DBS-STN turned on and off. We used psychological tests and questionnaires to evaluate cognitive function and the effects on mood from turning DBS-STN off. We applied a novel PET neuroimaging methodology to evaluate the integrity of the cerebral serotonin system. We measured 5-HT1BR binding in 13 DBS-STN-treated PD patients, at baseline and after turning DBS off. Thirteen age-matched volunteers served as controls. The measures for cognition and mood were correlated to the 5-HT1BR availability in temporal limbic cortex. 5-HT1BR binding was proportional to working memory performance and inverse proportional to affective bias for face recognition. When DBS is turned off, patients feel less vigorous; the higher the limbic and temporal 5-HT1BR binding, the more they are affected by DBS being turned off. Our study suggests that cerebral 5-HTR binding is associated with non-motor symptoms, and that preservation of serotonergic functions may be predictive of DBS-STN effects.Funding Information
- Lundbeck Foundation (R170 2014 994, R183 2014 3836)
- Independent Research Fund Denmark (F-23838-1)
- Aase og Ejnar Danielsens Fond (10-001296)
- Fonden til Lægevidenskabens Fremme (13-216)
This publication has 36 references indexed in Scilit:
- Importance of motor vs. non-motor symptoms for health-related quality of life in early Parkinson's diseaseParkinsonism & Related Disorders, 2013
- The serotonergic system in Parkinson's diseaseProgress in Neurobiology, 2011
- Bringing an Ecological Perspective to the Study of Aging and Recognition of Emotional Facial Expressions: Past, Current, and Future MethodsJournal of Nonverbal Behavior, 2011
- Parkinson's disease symptoms: The patient's perspectiveMovement Disorders, 2010
- Affective Cognition and its Disruption in Mood DisordersNeuropsychopharmacology, 2010
- Two Is Not Always Better Than OnePerspectives on Psychological Science, 2009
- The recognition of facial emotion expressions in Parkinson's diseaseEuropean Neuropsychopharmacology, 2008
- Dual-Processing Accounts of Reasoning, Judgment, and Social CognitionAnnual Review of Psychology, 2008
- An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challengeNeuroImage, 2006
- Neural structures associated with recognition of facial expressions of basic emotionsProceedings. Biological sciences, 1998