Comparison of effect of an increased dosage of vonoprazan versus vonoprazan plus lafutidine on gastric acid inhibition and serum gastrin
- 6 October 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Pharmacology
- Vol. 74 (1), 45-52
- https://doi.org/10.1007/s00228-017-2324-1
Abstract
Vonoprazan, a novel potassium-competitive acid blocker, elicits potent acid inhibition and hypergastrinemia at a dose of 20 mg. Its recommended maintenance dose for gastro-esophageal reflux disease is 10 mg, which is sometimes insufficient for preventing nocturnal acid breakthrough (NAB). Concomitant use of a histamine 2 receptor antagonist (H2RA) is effective for NAB. However, further acid inhibition by addition of H2RA has concern of hypergastrinemia again. Lafutidine (H2RA) is known to stimulate somatostatin release.Keywords
Funding Information
- a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (20590718)
This publication has 39 references indexed in Scilit:
- Effects of a novel histamine H2‐receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosaJournal of Gastroenterology and Hepatology, 2007
- Calcitonin gene-related peptide and somatostatin releases correlated with the area under the lafutidine concentration–time curve in human plasmaJournal of Clinical Pharmacy & Therapeutics, 2006
- Gastro‐oesophageal reflux associated with nocturnal gastric acid breakthrough on proton pump inhibitorsAlimentary Pharmacology & Therapeutics, 1998
- Appropriate Acid Suppression for the Management of Gastro-Oesophageal Reflux DiseaseDigestion, 1992
- Twenty four hour intragastric acidity and plasma gastrin concentration in healthy volunteers taking nizatidine 150 mg, nizatidine 300 mg, ranitidine 300 mg, or placebo at 21:00 h.Gut, 1988
- Omeprazole: Its Influence on Gastric Acid Secretion, Gastrin and ECL CellsToxicologic Pathology, 1988
- Pharmacology and Toxicology of Omeprazole with Special Reference to the Effects on the Gastric MucosaScandinavian Journal of Gastroenterology, 1986
- Effects of eight weeks' continuous treatment with oral ranitidine and cimetidine on gastric acid secretion, pepsin secretion, and fasting serum gastrin.Gut, 1983