Ovariektomili Ratlarda Gentamisin İle İndüklenen Akut Böbrek Hasarına Tarantula cubensis Ekstraktının Etkisi

Abstract

This study examined the effect of Tarantula cubensis extract (ICE) on gentamicin-induced acute kidney injury in ovariectomized rats. A total of 40 female Wistar albino rats were randomly divided equally into five groups: Control (C), ovariectomy (O), Tarantula cubensis (OT), gentamicin (OG), and gentamicin + Tarantula cubensis (OGT). All rats except those in the C were ovariectomized. Kidney damage was created with gentamicin for OG and OGT. The OT and OGT were treated with a single dose of TCE. Blood, sera, and kidney tissue were taken at necropsy for evaluation. Total leukocyte count was higher in the OT compared to the others (P=0.002). Significant increases were also determined in serum urea, creatinine, aspartate aminotransferase, and total protein levels in the OT, OG, and OGT compared to the C and O.The glutathione level was low in the serum and kidney tissue of the OG, and the malondialdehyde level was high compared to the others (P<0.05). As a result of the use of TCE in gentamicin-induced acute kidney injury in ovariectomized rats, serum creatinine, urea, and malondialdehyde levels decreased in the OGT compared to the OG, the glutathione level increased, and the severity of histopathological findings decreased to milder levels. As a result; single dose of TCE partially reduced kidney damage in rats with gentamicin-induced acute kidney injury.