Cytotoxic, antiglycation and carbonic anhydrase inhibition studies of chromium(III)-aroylhydrazine complexes
Open Access
- 30 September 2018
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 9 (3), 168-177
- https://doi.org/10.5155/eurjchem.9.3.168-177.1735
Abstract
In order to further reveal the chemistry and biochemistry of chromium(III) complexes, the present work illuminates the formation of chromium(III) complexes with aroylhydrazine ligands with their physical, chemical and spectral studies. Another significant contribution of this study is the evaluation of the cytotoxic activity, antiglycation property and carbonic anhydrase inhibition study of synthesized chromium(III)-aroylhydrazine complexes. Synthesis and structural investigation of aroylhydrazine ligands (1-7) and their chromium(III) complexes (1a-7a) were carried out by using elemental analysis (C, H, N), physical (conductivity measurements) and spectral (EI-Mass, ESI-Mass, FTIR and UV-Visible) methods. These physical, analytical and spectral data supports that all chromium(III)-aroylhydrazine complexes exhibit an octahedral geometry in which ligand exhibits as a bidentate coordination and two water molecules coordinated at equatorial positions with general formula [Cr(L)2(H2O)2]Cl3. Cytotoxic investigations shows that synthesized chromium(III)-aroylhydrazine complexes were not found to be toxic against normal cells so these compounds were further studied for other biological activities. Moreover, aroylhydrazine ligands and their chromium(III) complexes were examined for their antiglycation activity in which ligands were found inactive whereas chromium(III)-aroylhydrazine complexes showed significant inhibition of the process of protein glycation. Similarly, in carbonic anhydrase inhibition studies all aroylhydrazine ligands were observed inactive while some of chromium(III)-aroylhydrazine complexes showed potential in carbonic anhydrase inhibition.Keywords
This publication has 61 references indexed in Scilit:
- Significance of Advanced Glycation End Products in Aging-Related DiseaseANTI-AGING MEDICINE, 2010
- Synthesis and characterization of the chromium(III) complexes of ethylene cross-bridged cyclam and cyclen ligandsInorganica Chimica Acta, 2009
- Synthesis, Spectroscopy, and Biological Properties of Vanadium(IV)–Hydrazide ComplexesChemistry & Biodiversity, 2008
- Safety of trivalent chromium complexes: No evidence for DNA damage in human HaCaT keratinocytesFree Radical Biology & Medicine, 2007
- Carbonic Anhydrase Inhibitors. DNA Cloning, Characterization, and Inhibition Studies of the Human Secretory Isoform VI, a New Target for Sulfonamide and Sulfamate InhibitorsJournal of Medicinal Chemistry, 2006
- Carbonic anhydrase inhibitors: Inhibition of the transmembrane isozyme XIV with sulfonamidesBioorganic & Medicinal Chemistry Letters, 2005
- Cytotoxicity studies of chromium(III) complexes on human dermal fibroblastsFree Radical Biology & Medicine, 2005
- A Critical Assessment of Chromium in the EnvironmentCritical Reviews in Environmental Science and Technology, 1999
- Carbonic Anhydrase Inhibitors. Part Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IVMetal-Based Drugs, 1998
- Carbonic anhydrase inhibitors. Part 11. Coordination compounds of heterocyclic sulfonamides with lanthanides are potent inhibitors of isozymes I and IIJournal of Inorganic Biochemistry, 1993