Bioactivity of Olive Oil Phenols in Neuroprotection
Top Cited Papers
Open Access
- 25 October 2017
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 18 (11), 2230
- https://doi.org/10.3390/ijms18112230
Abstract
Neurological disorders such as stroke, Alzheimer’s and Parkinson’s diseases are associated with high morbidity and mortality, and few or no effective options are available for their treatment. These disorders share common pathological characteristics like the induction of oxidative stress, abnormal protein aggregation, perturbed Ca2+ homeostasis, excitotoxicity, inflammation and apoptosis. A large body of evidence supports the beneficial effects of the Mediterranean diet in preventing neurodegeneration. As the Mediterranean diet is characterized by a high consumption of extra-virgin olive oil it has been hypothesized that olive oil, and in particular its phenols, could be responsible for the beneficial effect of the Mediterranean diet. This review provides an updated vision of the beneficial properties of olive oil and olive oil phenols in preventing/counteracting both acute and chronic neurodegenerative diseases.Keywords
This publication has 210 references indexed in Scilit:
- Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trialThe journal of nutrition, health & aging, 2013
- Do polyphenols enter the brain and does it matter? Some theoretical and practical considerationsGenes & Nutrition, 2011
- Mediterranean diet and magnetic resonance imaging–assessed cerebrovascular diseaseAnnals of Neurology, 2010
- Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthalToxicology and Applied Pharmacology, 2009
- Mediterranean Diet and Mild Cognitive ImpairmentArchives of Neurology, 2009
- The neuroprotective potential of flavonoids: a multiplicity of effectsGenes & Nutrition, 2008
- Mediterranean Diet, Alzheimer Disease, and Vascular MediationArchives of Neurology, 2006
- The enzymic and chemically induced decomposition of glucosinolatesPhytochemistry, 2006
- Mediterranean diet and risk for Alzheimer's diseaseAnnals of Neurology, 2006
- Oxidative stress in Parkinson's diseaseAnnals of Neurology, 2003