Genetic, epigenetic, and post‐transcriptional basis of divergent tissue regenerative capacities among vertebrates
Open Access
- 17 May 2021
- journal article
- perspective
- Published by Wiley in Advanced Genetics
- Vol. 2 (2), e10042
- https://doi.org/10.1002/ggn2.10042
Abstract
Regeneration is widespread across the animal kingdom but varies vastly across phylogeny and even ontogeny. Adult mammalian regeneration in most organs and appendages is limited, while vertebrates such as zebrafish and salamanders are able to regenerate various organs and body parts. Here, we focus on the regeneration of appendages, spinal cord, and heart—organs and body parts that are highly regenerative among fish and amphibian species but limited in adult mammals. We then describe potential genetic, epigenetic, and post-transcriptional similarities among these different forms of regeneration across vertebrates and discuss several theories for diminished regenerative capacity throughout evolution.Keywords
Funding Information
- National Heart, Lung, and Blood Institute (R01HL138456)
- U.S. Department of Defense (W81XWH1910206)
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