Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction
Open Access
- 15 March 2023
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 14, 1142001
- https://doi.org/10.3389/fphar.2023.1142001
Abstract
Kidney is a key organ in human body to excrete toxins and sustain the balance of water and electrolyte. In its embryonic development and disease evolution, kidney endures enormous changes in macrostructure, accompanied by a variety of microstructural histological features of glomerular formation and sclerosis, tubule elongation and atrophy, interstitial establishment and fibrosis extension. All of these rely on the frequent occurrence of cell death and growth. Notably, to overcome the disease, some cells try to regenerate through self-repair or progenitor cell differentiation. However, the underlying signal mechanisms of kidney development and regeneration have not been elucidated. Recently, Wnt signaling has been noticed by scientists. Although as a well-known development signal under the spot light, the role of Wnt signaling in kidney development and regeneration is still not well-recognized. In this issue, we generally review the important role of Wnt signaling in kidney embryonic development and tissue repair of cell division, and progenitor cell differentiation after injury. Moreover, we briefly highlight advances in the understanding of the pathogenic mechanisms of Wnt signaling in mediating cellular senescence in kidney parenchymal and stem cells, an irreversible arrest of cell proliferation to resist repair and regeneration. We also highlight the therapeutic targets against Wnt signaling in kidney diseases and provide important clues for clinical strategies.This publication has 215 references indexed in Scilit:
- Renoprotective effect of the antioxidant curcumin: Recent findingsRedox Biology, 2013
- Evolving importance of kidney disease: from subspecialty to global health burdenThe Lancet, 2013
- Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in ratsIndian Journal of Pharmacology, 2013
- Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cellsToxicology and Applied Pharmacology, 2012
- Curcumin Induces Nrf2 Nuclear Translocation and Prevents Glomerular Hypertension, Hyperfiltration, Oxidant Stress, and the Decrease in Antioxidant Enzymes in 5/6 Nephrectomized RatsOxidative Medicine and Cellular Longevity, 2012
- Mitochondrial Protection by ResveratrolExercise and Sport Sciences Reviews, 2011
- A general introduction to the biochemistry of mitochondrial fatty acid β‐oxidationJournal of Inherited Metabolic Disease, 2010
- Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cellsBiochemical and Biophysical Research Communications, 2009
- Isoflavones Promote Mitochondrial BiogenesisThe Journal of pharmacology and experimental therapeutics, 2008
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1αThe EMBO Journal, 2007