Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults

Abstract

An important limitation of traditional clinical guidelines is the frequent dissociation between quality of evidence and strength of recommendations.^1-6 As a result, some past guideline recommendations have endorsed harmful care, which was only subsequently recognized when high-quality, prospective controlled trials were conducted.⁷ To overcome this limitation, we developed a novel approach, called WikiGuidelines, to establish clear recommendations only when high-quality, hypothesis-confirming evidence is available (see group charter in Supplement 1).