JAK-STAT Pathway: A Novel Target to Tackle Viral Infections
Open Access
- 27 November 2021
- Vol. 13 (12), 2379
- https://doi.org/10.3390/v13122379
Abstract
Modulation of the antiviral innate immune response has been proposed as a putative cellular target for the development of novel pan-viral therapeutic strategies. The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway is especially relevant due to its essential role in the regulation of local and systemic inflammation in response to viral infections, being, therefore, a putative therapeutic target. Here, we review the extraordinary diversity of strategies that viruses have evolved to interfere with JAK-STAT signaling, stressing the relevance of this pathway as a putative antiviral target. Moreover, due to the recent remarkable progress on the development of novel JAK inhibitors (JAKi), the current knowledge on its efficacy against distinct viral infections is also discussed. JAKi have a proven efficacy against a broad spectrum of disorders and exhibit safety profiles comparable to biologics, therefore representing good candidates for drug repurposing strategies, including viral infections.Keywords
Funding Information
- Instituto de Salud Carlos III (PI17/00624 and PI19/00194, CPII19/00012)
- CaixaBank (LCF/BQ/IN18/11660017)
- Government of Catalonia (SLT017/20/000090)
This publication has 93 references indexed in Scilit:
- Paramyxovirus evasion of innate immunity: Diverse strategies for common targetsWorld Journal of Virology, 2013
- Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells Inhibits Neutrophil Recruitment through an Interleukin-6-Dependent Mechanism: a New Paradigm for Viral Immune EvasionJournal of Virology, 2011
- Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon SignalingPLOS ONE, 2010
- Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte ApoptosisPLoS Neglected Tropical Diseases, 2010
- Epstein-Barr Virus Interferes with the Amplification of IFNα Secretion by Activating Suppressor of Cytokine Signaling 3 in Primary Human MonocytesPLOS ONE, 2010
- Respiratory Syncytial Virus Impairs Macrophage IFN-α/β– and IFN-γ–Stimulated Transcription by Distinct MechanismsAmerican Journal of Respiratory Cell and Molecular Biology, 2010
- The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT SignalingJournal of Virology, 2010
- NS5 of Dengue Virus Mediates STAT2 Binding and DegradationJournal of Virology, 2009
- Vaccinia Virus Blocks Stat1-Dependent and Stat1-Independent Gene Expression Induced by Type I and Type II InterferonsJournal of Interferon & Cytokine Research, 2008
- Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear AccumulationJournal of Virology, 2006