Ventilation and perfusion scintigraphy after lung transplantation
Open Access
- 10 September 2020
- journal article
- Published by IPO Association of Transplantologists in Transplantologiya
- Vol. 12 (3), 174-188
- https://doi.org/10.23873/2074-0506-2020-12-3-174-188
Abstract
Study objective.Evaluation of the possibilities of ventilation and perfusion scintigraphy in detecting functional disorders and determining the severity of lung damage that may occur after organ transplantation.Material and methods.The study included 27 patients after bilateral lung transplantation; mucoviscidosis was the main cause of terminal respiratory failure in most cases (19 patients; 77.8%). The ventilation scintigraphy was performed with99mTc-pentatech using a nebulizer, and the perfusion scintigraphy was performed with99mТс-albumin macroaggregate. The investigations were performed on Infinia II and Discovery 670 NM/CT single-photon emission tomographs (GE, USA).Results.Changes in the quantitative parameters of ventilation and perfusion scintigraphy in patients after lung transplantation were studied. When analyzing the results of radionuclide studies, we identified a restoration of function after lung transplantation, and the appearance of disorders with the development of complications in the early (up to 4 months) and later (more than one year) periods after bilateral lung transplantation.Conclusion.The study has shown that the radionuclide method has wide possibilities for assessing the ventilation and perfusion functions in patients after lung transplantation, helping in the differential diagnosis of obliterating bronchiolitis and graft vascular sclerosis, in assessing the nature of alveolar-capillary diffusion disorders, and determining the extent of functional abnormalities in every individual patient. Monitoring the function of transplanted lungs using scintigraphy allows separate monitoring of ventilation and perfusion changes, which is important for the choice of treatment tactics.This publication has 14 references indexed in Scilit:
- The Diagnosis and Management of Airway Complications Following Lung TransplantationSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2017
- Acute postoperative management after lung transplantationBest Practice & Research Clinical Anaesthesiology, 2017
- Long-term outcomes and management of lung transplant recipientsBest Practice & Research Clinical Anaesthesiology, 2017
- Baseline characteristics of idiopathic pulmonary fibrosis: analysis from the Australian Idiopathic Pulmonary Fibrosis RegistryEuropean Respiratory Journal, 2017
- Recent Advances in Mammalian Target of Rapamycin Inhibitor Use in Heart and Lung TransplantationTransplantation, 2016
- Lung transplantationCurrent Opinion in Anaesthesiology, 2016
- Organ donation and transplantation: An updated overviewMAMC Journal of Medical Sciences, 2016
- Airway complications post lung transplantationCurrent Opinion in Pulmonary Medicine, 2013
- Long-term Course and Prognosis of Idiopathic Pulmonary Fibrosis in the New MillenniumSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2011
- Diagnostic strategies for suspected pulmonary embolismPublished by European Respiratory Society (ERS) ,2004