Model of virus therapy and chemotherapy for cancer
Open Access
- 1 November 2019
- journal article
- research article
- Published by IOP Publishing in IOP Conference Series: Earth and Environmental Science
- Vol. 364 (1), 012029
- https://doi.org/10.1088/1755-1315/364/1/012029
Abstract
This article discusses the mathematical model of changes in the number of cancer cells as a result of the intervention. Here the effect of combination treatment, in the form of virus injection and chemotherapy on tumor cells, is presented in detail. There are two different tumor cells, uninfected tumor cells and infected tumor cells. Model simulations with different parameters were performed for 700 d. The initial values for the population of virus-infected tumor cells are divided into two categories. The number of tumor cells injected with the virus is ½ (half) and all tumor cells that are not infected. Based on the simulation results, it was concluded that the more the number of tumor cells injected with the virus, the faster the decrease in the number of tumor cell populations. It was also concluded that the reduced population of tumor cells reduces the amount of chemotherapy concentration used.Keywords
This publication has 9 references indexed in Scilit:
- Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysisMathematical Biosciences and Engineering, 2018
- Modelling the spatiotemporal dynamics of chemovirotherapy cancer treatmentJournal of Biological Dynamics, 2016
- Oncolytic virus therapy: A new era of cancer treatment at dawnCancer Science, 2016
- Dynamics of CancerPublished by World Scientific Pub Co Pte Ltd ,2013
- Oncolytic Viruses in the Treatment of Cancer: A Review of Current StrategiesPathology and Oncology Research, 2012
- Systemic Delivery of Oncolytic Viruses: Hopes and HurdlesAdvances in Virology, 2012
- Intelligent Design: Combination Therapy With Oncolytic VirusesMolecular Therapy, 2010
- Oncolytic virus therapy for prostate cancerInternational Journal of Urology, 2009
- Some mathematical models for cancer chemotherapyComputers & Mathematics with Applications, 1994