Background: The study of the length-weight relationship (LWR) and condition factor (K) are critical in fisheries research and management. However, there is currently a dearth of information on the growth pattern and state of health of Parachanna obscura in Epe lagoon Methods: A total of 252 species of P. obscura ranging from 19.50 to 36.70 cm (standard length = 28.22 ± 4.95 cm) and 58.80 to 331.00 g (total weight = 267.69 ± 72.16 g) were obtained from the catches of local fishermen at the chief market fish landing station monthly for six months (January – June, 2018) at Epe lagoon, Lagos, Nigeria. Standard Length (SL) and Body Weight (BW) were measured to the nearest 0.1 cm and 0.01 g using digital Vernier calliper and electronic precision balance, respectively. Length-Weight Relationships and condition factor (K) were calculated using standard formula. Data were analysed using descriptive statistics and ANOVA at α 0.05. Results: The LWRs for males, females and combined sexes were 2.60, 2.70, and 2.65, respectively, indicating a negative allometric growth pattern. The mean K value in females (1.36±0.70) was higher than in males (1.18±0.48). Conclusion: The findings indicated that Parachanna obscura in Epe lagoon, Nigeria were heavy and in good health within the study period