Flavonoids from the Leaves of Bridelia stipularis with in Vitro Antioxidant and Cytotoxicity Activity
Open Access
- 1 January 2020
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Pharmacology & Pharmacy
- Vol. 11 (07), 137-146
- https://doi.org/10.4236/pp.2020.117013
Abstract
Methanolic extract of the leaves of Bridelia stipularis was studied. From this study, we isolated three known flavonoids. They were identified as 7-O-methyl luteolin, apigenin and 5, 7, 2’, 5’ tetrahydroxyflavone by NMR spectroscopic studies. All of them are first time documented for this plant. Different solvent fractions were subjected to in vitro antioxidant and cytotoxicity studies. Both apigenin and ethyl acetate soluble fraction of Bridelia stipularis showed strong antioxidant activity having IC50 value of 8.005, 8.77 μg/mL respectively. Chloroform soluble fraction of Bridelia stipularis exerted the highest toxicity to brine shrimp and petroleum ether soluble fraction showed moderate toxicity having LC50 value of 1.05, 1.71 μg/mL respectively.Keywords
This publication has 14 references indexed in Scilit:
- Ethnobotany and Medicinal Uses of Folklore Medicinal Plants Belonging to Family Acanthaceae: An Updated ReviewMOJ Biology and Medicine, 2017
- Bioactive Steroid and Triterpenoids from Bridelia stipularis (L) BlumeDhaka University Journal of Pharmaceutical Sciences, 2017
- In Vitro Antioxidant and Thrombolytic Activities of Bridelia Species Growing in BangladeshJournal of Scientific Research, 2013
- A Historical Overview of Natural Products in Drug DiscoveryMetabolites, 2012
- Bridelia stipularis: a new source for anthocyanin production in vitroActa Physiologiae Plantarum, 2011
- The genus Bridelia: A phytochemical and ethnopharmacological reviewJournal of Ethnopharmacology, 2009
- Studies on the Constituents of Scutellaria Species (XXII). Constituents of the Roots of Scutellaria amabilis HARACHEMICAL & PHARMACEUTICAL BULLETIN, 2006
- (1231) Proposal to conserve the name Bridelia (Euphorbiaceae) with a conserved spellingTaxon, 1996
- Use of a free radical method to evaluate antioxidant activityLWT, 1995
- Brine Shrimp: A Convenient General Bioassay for Active Plant ConstituentsPlanta Medica, 1982