Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?
- 6 August 2020
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 131 (2), E677-E681
- https://doi.org/10.1002/lary.28989
Abstract
Objectives Familial non‐medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non‐medullary thyroid cancer (SNMTC). We seek to compare in this study, the clinicopathological variables, and the outcome of FNMTC versus SNMTC patients. Methods We retrospectively searched a database of 465 patients that underwent thyroidectomy at Assaf Harofeh Medical Center (91.4% between 1990 and 2019) for demographics, risk factors, medical history, diagnostic workup, primary treatment, follow‐up, and disease outcome data. We compared 47 FNMTC versus 321 SNMTC patients, and FNMTC patients with ≥2 (n = 34) versus ≥3 (n = 13) first‐relative affected members. Results There were no significant differences in demographics, histopathology, TNM stage, treatment, and disease outcome between the FNMTC and SNMTC groups. The T2 and T4 tumor stage in the ≥3‐member group were 25% and 8.3% compared to 0% and 0% in the two‐member group (P = .02 and P = ns, respectively). Also, LN involvement was significantly higher in the ≥3‐member group (61.6% vs. 24.2%, respectively; P = .036). Conclusion FNMTC is not a more aggressive disease than SNMTC, but this may not apply for the ≥3‐affected‐relatives group. A large multicenter study including only families with three or more affected relatives is needed. Until then, a family history of NMTC should not be overlooked. Level of Evidence 3/5 Laryngoscope , 2020Keywords
This publication has 26 references indexed in Scilit:
- Familial non-medullary thyroid cancer: unraveling the genetic mazeEndocrine-Related Cancer, 2016
- The impact of family history on non-medullary thyroid cancerEuropean Journal of Surgical Oncology, 2016
- In Patients with Thyroid Cancer of Follicular Cell Origin, a Family History of Nonmedullary Thyroid Cancer in One First-Degree Relative Is Associated with More Aggressive DiseaseThyroid®, 2012
- Familial thyroid cancer: a reviewLaboratory Investigation, 2011
- On the Prevalence of Familial Nonmedullary Thyroid Cancer in Multiply Affected KindredsThyroid®, 2006
- Familial Nonmedullary Thyroid Carcinoma Characterized by Multifocality and a High Recurrence Rate in a Large Study PopulationWorld Journal of Surgery, 2002
- Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter seriesSurgery, 2000
- Familial nonmedullary thyroid cancer.Current Treatment Options in Oncology, 2000
- On the Prevalence of Familial Nonmedullary Thyroid CancerThyroid®, 1998
- Familial Nonmedullary Thyroid CancerArchives of Surgery, 1995