The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis
Open Access
- 20 August 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 394 (10), 1991-2002
- https://doi.org/10.1007/s00210-021-02131-0
Abstract
The current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.Keywords
Funding Information
- Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (2021KY028)
This publication has 99 references indexed in Scilit:
- Gold nanoparticles stimulate differentiation and mineralization of primary osteoblasts through the ERK/MAPK signaling pathwayMaterials Science and Engineering: C, 2014
- Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 AxisCell, 2014
- Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological ChangesBioMed Research International, 2014
- Effects of gold and silver nanoparticles in cultured human osteoarthritic chondrocytesJournal of Applied Toxicology, 2013
- Manganese and the BrainInternational review of neurobiology, 2013
- Targeted Chemo-Photothermal Treatments of Rheumatoid Arthritis Using Gold Half-Shell Multifunctional NanoparticlesACS Nano, 2012
- Molecular modeling of the relationship between nanoparticle shape anisotropy and endocytosis kineticsBiomaterials, 2012
- The role of synovitis in osteoarthritis pathogenesisBone, 2012
- α v β 3 –Targeted nanotherapy suppresses inflammatory arthritis in miceThe FASEB Journal, 2009
- VEGFA is necessary for chondrocyte survival during bone developmentDevelopment, 2004