Tumor suppressive functions of LZTFL1 in hepatocellular carcinoma
Open Access
- 1 July 2019
- journal article
- research article
- Published by Taylor & Francis Ltd in OncoTargets and Therapy
- Vol. ume 12, 5537-5544
- https://doi.org/10.2147/ott.s196925
Abstract
Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. The poor survival may be due to tumor recurrence and metastasis. Growing evidence indicates that Leucine Zipper Transcription Factor-like 1 (LZTFL1) plays an important role in tumor progression of several cancers such as lung cancer and gastric cancer. Methods: Real-time PCR was performed to evaluate LZTFL1 expression level in HCC cell lines and patient specimens. The relationship between LZTFL1 expression and the clinicopathological data of the patients was analyzed. Stable cell lines with overexpressing LZTFL1 were set-up, and the cell proliferation, migration, and invasion abilities were analyzed. The protein expression was measured by Western blotting. Results: Here, we found LZTFL1 expression was decreased in human HCC specimens and HCC cell lines. Downregulation of LZTFL1 expression was correlated with tumor stage and metastasis. The ectopic overexpression of LZTFL1 inhibited cell proliferation, migration, invasion, and the expression of MMP9. In addition, LZTFL1 suppressed epithelial mesenchymal transition (EMT). Conclusion: Taken together, our results highlight the tumor suppressive role of LZTFL1 in HCC, suggesting that LZTFL1 may represent a potential therapeutic strategy for treating patients with HCC.Keywords
This publication has 23 references indexed in Scilit:
- The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma CellsNano Letters, 2017
- Understanding the molecular mechanisms driving metastasisMolecular Oncology, 2017
- Role of epithelial to mesenchymal transition in hepatocellular carcinomaJournal of Hepatology, 2016
- Cancer statistics in China, 2015CA: A Cancer Journal for Clinicians, 2016
- LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cellsOncogene, 2015
- LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-cateninZeitschrift für Krebsforschung und Klinische Onkologie, 2014
- Molecular mechanisms of epithelial–mesenchymal transitionNature Reviews Molecular Cell Biology, 2014
- Matrix Metalloproteinases and Cancer - Roles in Threat and TherapyAsian Pacific Journal of Cancer Prevention, 2014
- Epithelial‐to‐mesenchymal transition predicts prognosis in clinical gastric cancerJournal of Surgical Oncology, 2014
- Tumor-Suppressive Functions of Leucine Zipper Transcription Factor–Like 1Cancer Research, 2010