Henry Reaction between Benzaldehyde and Nitromethane over Solid Base Catalysts: A Green Protocol

Abstract

The development of environmentally benign solid base catalysts instead of the soluble bases for C-C bond formation in organic reactions especially Henry reactions with nitroalkanes compounds is of intense research activity in the bulk and fine chemical chemistry in order to achieve the selectivity of the desired product and the reduction of the salts formed due to soluble bases neutralization. While using of LDHs catalysts in the synthesis of nitro alcohols is of great interest because LDHs (double layered hydroxides) is of unique properties and an excellent catalytic property. The nitroalcohols are obtained in a very good yield while using catalyst either by conventional at 90°C in liquid phase, microwave or sonoenergy without solvent methods, and the results yields are compared. A series of different nitro alcohols from (a - o) were prepared, the catalytic test reaction were carried out using benzaldehyde and their derivatives with nitromethane and their derivatives. A series of LDHs catalysts were prepared also and studying of the catalytic effect on the reactions was carried out. Properties of the compounds prepared were characterized by IR, MNR, and GC-MS.